Posted on February 10th, 2017 in Anita Bandrowski, Force11, News & Events | No Comments »
Science is the act of trying and trying again, whether or not we confirm what we think should be happening.
Begely and Ellis in their 2012 paper from Amgen stated that only about 11% of cancer studies were replicable sending shockwaves through the scientific community for years. However, the authors did not give the scientific community all of the data that showed the replicates.
This week in eLife, the Center for Open Science and a cohort of great ‘re-do-ers’ have just published the first batch of studies that are replicates of influential cancer studies, attempting to confirm or deny what the original study claimed. We at the RRID initiative have noted that the original studies often lacked identifying information in the reagents they used, as is alluded to by some of the replication attempts. These simple omissions make replication much more difficult, something that the ‘re-do-ers’ struggled with.
This is really a monumental step and we will wait for the final publications to determine whether these rigorous and fully transparent attempts also fall in the 11% replication level as claimed by Begely and Ellis, but so far some of the replicates show trends in the same direction reported by the original study authors, though no replication attempt has panned out exactly the same way as the original paper. We certainly need to wait and see for the rest of the reports, but I am personally heartened that the original authors are engaged in the replication, commenting on these reports attempting to understand their own data and the new data.
The immortal Aristotle was once reported to say “Quality is not an act, it is a habit.” I think that if he were alive today he would be very interested in these developments and would implore us to look at ourselves and if we did not like what we see, he would call on us to change for the better. While none of my papers will likely be the target of this kind of scrutiny, I do hope that the methods and results will stand up in the long term. This is a call to action for all of us, to be more precise and to do better delivering on the promise of science for the patients who deserve our very best attention and very best methodology.
Hello NIF/SciCrunch Community!
Please read below for a funding opportunity from the Kavli Institute for Brain and Mind.
“Dear KIBM Community,
The Kavli Institute for Brain and Mind is now inviting applications for Innovative Research Grants (IRGs) to support novel and interdisciplinary brain-mind research in 2017-18.
Please review the attached file and the following website for program details:
The deadline for proposals will be Friday, March 31, 2017.
This grant program was made possible by generous support from The Kavli Foundation.
Nick Spitzer and Rusty Gage
Co-Directors, Kavli Institute for Brain and Mind”
Follow the link above for more information on the application procedure!
The NIF/SciCrunch team
On behalf of all of us at the Neuroscience Information Framework and the SciCrunch Community, we would like to wish you the most splendid of holiday seasons. We hope your vacation season is relaxed and safe. As we enter through the new year be sure to stay updated with our partner sites on Facebook and Twitter (@scicrunch @neuinfo @dk_net) so that we can keep you updated on all of the exciting developments in the world of Neuroscience in 2017.
The Neuroscience Information Framework Team
Come one come all, listen to a podcast on reproducibility on your way home today.
“Talkin’ Immunology” hosts a conversation about Rigor and Transparency.
One week left to apply INCF seed funding projects. Submit your application no later than November 30, 2016. Read below for more information on the grants.
“INCF* invites applications for seed funding of collaborative brain research projects. The deadline for submission is no later than November 30, 2016. Projects must be completed within 2017.
Seed funding grants should facilitate community work in collaborative brain research, promote the use of neuroinformatics solutions, and accelerate advances in understanding the brain and treating its illnesses.There are two types of funding available, project funding and travel grants.
Travel grants will be used to support collaborative work. One of the collaborators (traveller or host) must be based in one of the 17 INCF network countries. The proposed travel should support one or more of the following:
- exchange of information relevant to neuroinformatics between parties based in different countries
- progression of work relevant to neuroinformatics requiring the participant to travel to another location, usually another country, for collaboration
- participation in neuroinformatics training or education as a lecturer or participant (but not general attendance at scientific meetings)
Project funding supports projects that will deliver tools, data, research, education, training or community development, for example:
- driving forward delivery of a product that addresses a neuroscience use case
- enable a project to develop to the stage of attracting larger-scale external funding, for example initial consortium meetings or pilot data collection
- organisation and hosting of a scientific workshop
- development of training or educational content
The funding could facilitate, for example: initial consortia formation for the creation of a competitive funding proposal; work to demonstrate a proof of concept; tool development or integration; hosting of a workshop to explore and develop an area; or development of education and training content. The leader of a funded proposal must be based in one of the 17 countries in the INCF network.
All participants of a funded proposal must commit to sharing all reports, data, code, and training/education materials from the final project, subject to any limitations imposed by any subsequent funder. Projects must be completed within 2017.
More information and FAQ: https://www.incf.org/resources/funding-support
*INCF is an international organization launched in 2005, following a proposal from the Global Science Forum of the OECD to establish international coordination and collaborative informatics infrastructure for neuroscience. The INCF international network currently spans North America, Europe, Australia and Asia. INCF fosters the global digital interconnectivity of data, methods and people engaged in brain research to catalyze insights into brain function in health and disease.”
So I never ever put apps on my phone because they are a waste of space, also I have an old sad phone so a couple of apps just decimate up my memory.
This all changed at the 2016 SfN meeting last week when I talked to some lovely grad students from Norway, who showed me Neuronify. Ok I know what you are thinking, how can an app for something neuroscience-related actually be useful? I was certainly a skeptic, but no longer.
You have got to try it!
I am an electrophysiologist, by training, and always wondered why anyone in their right mind would ever simulate data. Isn’t that like making things up?
Then I started simulating data on some nice Cray supercomputers, because it was fun, but it is a little inconvenient to lug one of those to class or a dinner date.
Neuronify solves this problem, at least for relatively simple simulations, allowing students to quickly see how neurons behave in a network while doing what they do all day anyway, i.e., play with their phones.
I can’t say enough about how much fun I am having with my phone, now that I can simulate Tritonia swimming central pattern generator circuits, without having to find snails!
Hello NIF/SciCrunch Community!
Our partners at INCF are inviting applications for “seed funding of collaborative brain research projects.” Please click the link for more details!
The NIF/SciCrunch team
Hello SciCrunch/NIF Community!
Please read below for information on registering for Brainhack Los Angeles!
“Registration is now open for Brainhack Los Angeles – Big Data Tools for Connectomics (http://events.brainhack.org/LA2016/)! This 3-day workshop will be held November 10-12 in Los Angeles, California just before the 2016 Society for Neuroscience (SFN) Annual Meeting. Brainhack events (http://brainhack.org) bring researchers from disparate backgrounds together to collaborate on problems in neuroscience. Brainhack Los Angeles is supported by and brings together the incredible expertise of two NIH BD2K Centers, ENIGMA [http://enigma.ini.usc.edu/] and Big Data for Discovery Science [http://bd2k.ini.usc.edu/]), and a NIH P41 Center, ReproNim: Center for Reproducible Neuroimaging Computation [http://www.reproducibleimaging.org/]). Email email@example.com for more information.”
The SciCrunch/NIF team
Hello NIF/SciCrunch Community!
Been craving some good news for open annotation? Well this recent news press should cheer you up!
“eLife, a non-profit initiative inspired by research funders and led by scientists, is working with Hypothes.is to bring publishers and researchers an open annotation platform for important online discussions.”
The NIF/SciCrunch (and hypothes.is) team